Hormone Replacement With Estradiol
Evidence From the Danish Osteoporosis Study
Estradiol Intervention Reduces Cardiovascular and Stroke Risks
With No Increase in Blood Clots or Breast Cancer
Worldlink Medical Journal Club* Practitioners Discuss
the Danish Study
Presented by Dr. Keith Nichols
(Click study image to download full text .pdf)
HRT and osteoporosis study conducted from 1990-2003, comparing placebo vs. oral estradiol + progestin or unopposed oral estradiol
- 502 patients took triphasic oral estradiol (1-2MG) +/- norethisterone acetate
- 504 patients took placebo
- longest oral estradiol study (> 10 years)
- study terminated at 10.1 years after the findings of the Women's Health Initiative were released
- Journal Club* panel conclusions
- oral estradiol is safe with
- no increase in heart disease
- reduced cardiovascular risk
- no increase in DVTs
- no increased risk for VTE/PE
- decreased risk of CVA
- decreased risk of breast cancer
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Journal Club
In-depth analysis of the most important hormone studies (3 per month) by respected members of the Worldlink community
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Dr. Neal Rouzier and other guest speakers present evidence-based pearls to treat your patients with proven protocols
