Meta-Analysis of Cohort Studies and Randomized Trials Progesterone and Breast Cancer
Evidence that Progesterone Protects Breast Tissue
Worldlink Medical Journal Club* Practitioners Discuss
the Impact of Progesterone on Breast Cancer Risk
Presented by Dr. Ashok Kadambi
Meta analysis and systematic review published in Climacteric, January, 2018
Journal Club* panelist conclusions:
- estrogens increase breast tissue proliferation
- micronized progesterone reduces breast density
- synthetic progestogens do not reduce breast density
- micronized progesterone had a relative risk ratio for breast cancer of 0.67 to 0.9 when compared to synthetic progestogens
- relative risk of breast cancer is 1.4 to 1.98 with synthetic progestogens
- increased breast cancer risk persists after 5 years of treatment (RR=1.34) with synthetic progestogens
- Dr. Kadambi tells his patients "5 years have been shown to be absolutely safe . . . Why don't we do [progesterone+estradiol] for 5 years, then reassess every 5 years?"
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