Worldlink Journal Club Discussion Progesterone and Breast Cancer

​Meta-Analysis of Cohort Studies and Randomized Trials Progesterone and Breast Cancer
​​Evidence ​that Progesterone Protects Breast Tissue

Worldlink Medical Journal Club* Practitioners Discuss
the Impact of Progesterone on Breast Cancer Risk
Presented by Dr. Ashok Kadambi

Progesterone and Breast Cancer

​(Click study image to download full text .pdf)

Meta analysis and systematic review published in Climacteric, January, 2018 

Journal Club* panelist conclusions:

  • estrogens ​increase breast tissue proliferation
  • micronized progesterone reduces breast density
  • synthetic progestogens do not reduce breast density
  • ​micronized progesterone had a relative risk ratio for breast cancer of 0.67 to 0.9 when compared to synthetic progestogens
  • ​relative risk of breast cancer is 1.4 to 1.98 with synthetic progestogens
  • increased breast cancer risk persists after 5 years of treatment (RR=1.34) with synthetic progestogens
  • Dr. Kadambi tells his patients "5 years have been shown to be absolutely safe . . . Why don't we do [progesterone+estradiol] for 5 years, then reassess every 5 years?"
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